The newest class of antihypertensive drugs synthesized in the early 1990s. These compounds block the renin-angiotensin cascade on the periphery, acting directly in the location of the receptors, that is, in the vascular wall, and do not affect the production of angiotensin II .
When using angiotensin receptor blockers (ARBs), vascular resistance decreases without reducing cardiac output. In some patients, heart rate may increase. There are no significant changes in blood lipid profile or blood glucose. Renal sprinkling pressure, systemic vascular resistance and plasma aldosterone level. It is recommended to start treatment with Cozaar with 25 mg once a day, its dose can be increased to 50-100 mg per day. The main way to eliminate this drug and its active metabolite is hepatic, therefore Losartan is not contraindicated for diabetic nephropathy and liver failure. Some studies have shown a positive effect of Losartan on diabetic nephropathy and microproteinuria.
Another representative of this class of drugs is Valsartan (Diovan) . As a result of a recent 8-month study on the use of Diovan in patients with arterial hypertension, data were obtained demonstrating that using Diovan results in a more pronounced decrease in left ventricular hypertrophy than with -blockers. The drug is prescribed in a dose of 80-160 mg per day.
The efficacy and features of the use of ARBA class drugs are still the subject of many clinical trials of the present time. The cost of these drugs is as high as ACE inhibitors.