In moderate to severe addison’s disease, hormone replacement therapy with gluco- and mineralo is prescribed. corticoids. The dose and type of drug are selected individually. Cortisone or hydrocortisone is administered intramuscularly at a dose of 12.5–50 mg per day, either orally or prednisone 5-20 mg, dexamethasone 1-2 mg per day, etc. In the absence of sufficient clinical effect etc.) additionally prescribe drugs with mineralocorticoid properties (deoxycorticosterone acetate – DOXA, deoxycorticosterone trimethyl acetate). DOXA is prescribed intramuscularly in the form of a 0.5% oil solution in 5 mg daily, every other day or 2 times a week or in the form of tablets for sublingual administration in 5 mg 2–4 times a day. DOXA tablets of 100–200 mg are used for subcutaneous implantations, the therapeutic effect of replanting is from 3 months to 1 year. Deoxycorticosterone trimethyl acetate is prescribed intramuscularly in the form of an aqueous 2.5% suspension of 1 ml once every 2-3 weeks.
With newly discovered addison disease, stressful situations (infections, injuries, etc.), it is advisable to inject corticosteroids parenterally, and when eliminating the symptoms of hypocorticism, orally. Corticosteroid preparations are prescribed internally, taking into account the daily rhythm of corticosteroid release: 2/3 daily dose in the morning and 1/3 after dinner. Typically, the daily maintenance dose of cortisone is 37.5-50 mg, and prednisolone, 10 mg. In stressful situations, the dose of corticosteroids is increased 2-3 times.