The antianginal activity of drugs in this group is slightly lower than that of calcium antagonists. In some cases, there is evidence of the occurrence of myocardial ischemia by the mechanism of “stealing”. At the same time,

The newest class of antihypertensive drugs synthesized in the early 1990s. These compounds block the renin-angiotensin cascade on the periphery, acting directly in the location of the receptors, that is, in the vascular wall, and do

Diuretics have been used successfully for the treatment of hypertension since the mid-1950s. The exact mechanism of the hypotensive action of diuretics is unknown, despite the fact that they have been used for this purpose

In patients with diabetes mellitus, diuretics in arterial hypertension are rarely used as monotherapy, more often in combination with drugs of the considered groups. Among the various classes of diuretics (thiazide, loop, potassium-saving, osmotic) it

Calcium channel blockers or calcium antagonists. All calcium antagonists are very powerful peripheral vasodilators and deplete blood pressure, reducing OPS . Preparations of this group have a specific ability to inhibit the penetration of calcium ions into smooth

Blockers of  – adrenergic receptors inhibit the effects of  – adrenergic stimuli on various organs. Stimulation of the  – receptors leads to renin release, vasodilation, bronchodilatation, an increase in cardiac output and pulse; increased insulin secretion, glycogenolysis, gluconeogenesis in the liver

Drugs of this class are now rarely used, mainly due to the emergence of new, better tolerated drugs. Two drugs, guanethidine (Ismelin) and guanadrel (Gilorel) , however, are very effective and inhibit the activity of the sympathetic

The last decade was marked by a new breakthrough in the study of genes encoding proteins involved in the regulation of blood pressure and vascular tone. The study of genetic predisposing factors for arterial hypertension in