Central diabetes insipidus

Etiology  Diabetes mellitus develops due to inadequate synthesis and / or secretion of antidiuretic hormone (central form), or the inability of the kidneys to respond adequately to circulating vasopressin (renal form). In endocrinological practice, diabetes

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Etiology  Diabetes mellitus develops due to inadequate synthesis and / or secretion of antidiuretic hormone (central form), or the inability of the kidneys to respond adequately to circulating vasopressin (renal form). In endocrinological practice, diabetes

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Neurosurgical interventions

One of the most common causes of central diabetes insipidus in children is the neurosurgical destruction of vasopressin neurons after surgery on the hypothalamic-pituitary area. It is important to distinguish polyuria associated with postoperative central

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One of the most common causes of central diabetes insipidus in children is the neurosurgical destruction of vasopressin neurons after surgery on the hypothalamic-pituitary area. It is important to distinguish polyuria associated with postoperative central

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Infiltrative, autoimmune and infectious diseases

Histiocytosis of Langerhans cells and lymphocytic hypophysitis are the most common infiltrative diseases causing diabetes insipidus. About 10% of patients with histocytosis have diabetes insipidus diabetes, and polyuria may precede the detection of intracranial damage

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Histiocytosis of Langerhans cells and lymphocytic hypophysitis are the most common infiltrative diseases causing diabetes insipidus. About 10% of patients with histocytosis have diabetes insipidus diabetes, and polyuria may precede the detection of intracranial damage

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Congenital anatomical defects

Anatomical defects of the midbrain, such as septo-optical dysplasia with the agenesis of the corpus callosum, holoprocephalus, etc., may be associated with central diabetes insipidus. These patients do not always have external signs of cranial-anomalies. Primary

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Anatomical defects of the midbrain, such as septo-optical dysplasia with the agenesis of the corpus callosum, holoprocephalus, etc., may be associated with central diabetes insipidus. These patients do not always have external signs of cranial-anomalies. Primary

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Clinical manifestation

In newborns and infants, the clinical picture of diabetes insipidus is significantly different from that in adults, and difficult enough to diagnose. These patients cannot express a desire for increased fluid intake, and if the

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In newborns and infants, the clinical picture of diabetes insipidus is significantly different from that in adults, and difficult enough to diagnose. These patients cannot express a desire for increased fluid intake, and if the

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Laboratory research

If all the history and clinical status data indicate the presence of pathological polyuria / polydipsia, the following blood and urine parameters should be investigated on an outpatient basis: serum osmolarity; serum sodium, potassium, calcium,

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If all the history and clinical status data indicate the presence of pathological polyuria / polydipsia, the following blood and urine parameters should be investigated on an outpatient basis: serum osmolarity; serum sodium, potassium, calcium,

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Fluid restriction test

The test with the restriction of liquids allows you to establish the diagnosis of diabetes insipidus and to conduct a differential diagnosis between nephrogenic and central non-diabetes mellitus. The principle of this test is that

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The test with the restriction of liquids allows you to establish the diagnosis of diabetes insipidus and to conduct a differential diagnosis between nephrogenic and central non-diabetes mellitus. The principle of this test is that

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Magnetic resonance imaging

Magnetic resonance imaging of the brain is essential in the diagnosis of central diabetes insipidus. Normally, the neurohypophysis is a region of bright glow in T1-weighted images. A bright spot of the neurohypophysis is absent

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Magnetic resonance imaging of the brain is essential in the diagnosis of central diabetes insipidus. Normally, the neurohypophysis is a region of bright glow in T1-weighted images. A bright spot of the neurohypophysis is absent

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Minirin treatment regimen

It is recommended to prescribe Minirin (0.1 mg / 0.2 mg) in tablets 30-40 minutes before a meal or 2 hours after a meal. Adequate dose of Minirin is selected mainly during the first 3-4 days

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It is recommended to prescribe Minirin (0.1 mg / 0.2 mg) in tablets 30-40 minutes before a meal or 2 hours after a meal. Adequate dose of Minirin is selected mainly during the first 3-4 days

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Epidemiology of patients with diabetes mellitus

Arterial hypertension occurs in more than 50% of patients with diabetes mellitus, primarily type 2 diabetes, and is a risk factor for developing coronary heart disease, acute myocardial infarction, cardiac rhythm disturbances, and cardiovascular failure.

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Arterial hypertension occurs in more than 50% of patients with diabetes mellitus, primarily type 2 diabetes, and is a risk factor for developing coronary heart disease, acute myocardial infarction, cardiac rhythm disturbances, and cardiovascular failure.

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